Humanized antibodies to CD38

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20020164788A1
SERIAL NO

09797941

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a monoclonal antibody, preferably with specificity for CD38, having CDRs of foreign origin and a recipient framework region having a sequence of human or primate origin, wherein the original amino acid residues in position 29 and/or 78 of the sequence of the recipient framework region of the heavy chain is replaced by a replacement amino acid residue that is the same or similar to that in the corresponding position of the sequence of the corresponding framework region of the heavy chain of the antibody from which the CDRs are derived. The invention also relates to a method of preparation of the antibody, a pharmaceutical composition containing the antibody and a method of using the antibody for the treatment of cancer and autoimmune diseases.

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Patent Owner(s)

Patent OwnerAddress
WELLCOME FOUNDATION LIMITED THEBERKLELEY AVENUE GLAXO WELLCOME HOUSE GREENFORD MIDDLESEX UB6 0

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ellis, Jonathan Henry Stevenage, GB 51 481
Lewis, Alan Peter Stevenage, GB 53 492

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