Devices and methods for high throughput patch clamp assays
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United States of America Patent
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Issued Date -
Nov 7, 2002
app pub date -
Dec 21, 2001
filing date -
Feb 9, 2001
priority date (Note) -
Abandoned
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Abstract
A device for measuring electrophysiological properties of a cell membrane of an individual cell comprises a plate provided with at least one opening. The opening is bounded by a surface and the surface is modified, such as via heat treatment, to facilitate formation of a gigaseal. A chamber is adjacent to the plate. The chamber is in fluid communication with at least one opening and is adapted to hold an electrically conductive solution. The plate further comprises a first electrode located in the chamber and a second electrode located adjacent to the plate.
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