Sulpur derivatives containing a retroamide bond as inhibitors of endothelin-converting enzymes
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United States of America Patent
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Issued Date -
Oct 31, 2002
app pub date -
Jan 16, 2002
filing date -
Mar 4, 1996
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Abandoned
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Abstract
The following products: [S--R.sup.+, S.sup.+)] N-[1-(mercaptomethyl)-2-phenylethyl]-alpha-[[phenyl-methoxy) carbonyl] amino]-1H-indole-3-propanamide, 2'-cyano-alpha-[[[1-mercaptomethyl)-2-phenylethyl] amino] carbonyl] (1,2'-biphenyl)-4-propanoic acid, (R)N-(1-mercaptomethyl)-2-phenylethyl)-11-phenoxy-undecanamide, said products being in all possible racemic, enantiomeric and diastereoisomeric forms, as well as the addition salts with pharmaceutically acceptable mineral and organic bases of said products of formula (I) having an inhibitory activity on enothelin-converting enzymes.
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