Identification of a new member of the cytochrome P450 3A (CYP3A): gene family: CYP3AX
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Oct 31, 2002
app pub date -
Nov 9, 2001
filing date -
May 30, 2000
priority date (Note) -
Published
status (Latency Note)
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Abstract
The present invention relates to polynucleotides encoding the CYP3AX protein and variants thereof. Further, the present invention also provides vectors comprising said polynucleotides, in particular vectors, wherein polynucleotides of the present invention are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells. In addition, the present invention relates to proteins encoded by said polynucleotides and antibodies specifically recognizing such proteins. The present invention also concerns transgenic non-human animals comprising the above-described polynucleotide or vectors. Moreover, the present invention relates to methods for identifying and obtaining drug candidates and inhibitors for therapy of disorders related to the malfunction of the CYP3AX genes as well as to methods of diagnosing the status of such disorders. The present invention also relates to methods for the identification of molecular variants of the CYP3AX polynucleotide or protein. The present invention furthermore provides pharmaceutical and diagnostic compositions comprising the above-described polynucleotides, vectors, proteins, antibodies, drugs and inhibitors obtainable by the above-described method. Said compositions are particularly useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of CYP3AX genes or their product.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| US | B1 | US6645745 | May 30, 2000 |
International Classification(s)
- 2001 Application Filing Year
- C07H Class
- 3167 Applications Filed
- 780 Patents Issued To-Date
- 24.63 % Issued To-Date
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