Affinity maturation by competitive selection
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United States of America Patent
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Issued Date -
Oct 24, 2002
app pub date -
Oct 30, 2001
filing date -
Oct 30, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method of selecting binding pair members with enhanced binding affinity for the cognate binding partner relative to a reference binding pair member. In particular, the invention provides methods of selecting antibodies with enhanced affinity for an antigen relative to a reference antibody. This process, 'affinity maturation', thereby provides antibodies with superior binding capabilities.
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