Car modulators: screening and treatment of hypercholesterolemia
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United States of America Patent
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Issued Date -
Oct 17, 2002
app pub date -
Jan 12, 2001
filing date -
Jan 13, 2000
priority date (Note) -
Abandoned
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Abstract
This invention provides methods that are useful for identifying therapeutic agents for the treatment of a CAR-mediated disorder or condition. The methods include determining whether the candidate therapeutic agent can: interact directly with CAR, modulate CAR-mediated gene expression, decrease CAR antagonist elevation of a cholesterol indicator in a mammal, or decrease a cholesterol level indicator in a mammal with a defective CAR. Also provided are CAR agonists.
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