PROCESS FOR PREPARING 1,4-DISUBSTITUTED PIPERIDINE COMPOUNDS
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United States of America Patent
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Issued Date -
Oct 17, 2002
app pub date -
Jan 31, 2000
filing date -
Mar 11, 1997
priority date (Note) -
Abandoned
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Abstract
The invention concerns a process for preparing 1,4-disubstituted piperidine compounds of formula (I), in which Y =-(CH2) n , n being 0. 1. 2 or 3; oxygen; sulphur; vinyl, -CH 2 -0-; -0-CH 2; -CH 2 -S- or -S-CH 2 , and R and Z mean substituents known per se. Compounds in which Z means -CH 2 -CH 2 - are produced in that the correspondingly substituted 5,6-dihydro- 11 H -benzo[5,6]-cyclohepta-[1,2-b] pyridin-11-one compound is reacted with the corresponding 1-substituted 4-piperidone in a single process step by means of reductive dimerization in the presence of a finely dispersed metal of the IVth and/or Vth and/or VIth subgroup of the periodic table of elements or a low-valent oxidation stage of a corresponding metal compound of this type, the finely dispersed metal or the low-valent oxidation stage being produced in situ by means of a reducing agent and in the presence of an inert solvent. Preferably 4-(5.6-dihydro- 11 H -benzo-[5,6] cyclohepta[1 ,2-b] pyridin-11-ylidene)-1-piperidine compounds are produced.
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