Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors

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United States of America Patent

APP PUB NO 20020151550A1
SERIAL NO

10100697

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are compounds of the formula: 1 or the pharmaceutically acceptable non-toxic salts thereof wherein: A, B, C. and D are N or CH; X is a bond or (un)substituted CH.sub.2; R.sub.1 is lower alkenyl or (un)substituted lower alkyl; R.sub.3 is lower alkyl; and R.sub.2, R.sub.4, R.sub.5, and R.sub.6 are variables defined herein; which compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatroy disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility or glaucoma, or for the increase of permeability of blood-brain barrier, pain, asthma, and rhinitis.

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Patent Owner(s)

Patent OwnerAddress
NEUROGEN CORPORATIONBRANFORD CT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brielmann, Harry L Guilford, CT 7 177
DeSimone, Robert W Durham, CT 43 1516
Hutchison, Alan Madison, CT 115 1411
Lew, Richard Hamden, CT 4 26
Maynard, George D Clinton, CT 59 378
Peterson, John M Madison, CT 68 404
Shaw, Kenneth Weston, CT 73 1685

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