Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
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United States of America Patent
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Issued Date -
Oct 10, 2002
app pub date -
Apr 3, 2002
filing date -
Apr 3, 2001
priority date (Note) -
Abandoned
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Abstract
Bifunctional capture probes used for multiplexed assays consist of particles bearing analyte-binding moieties and pairing oligonucleotides, which hybridize to an array of surface-bound capture oligonucleotides. Capture probes are combined with a sample containing analytes of interest, extracted from the sample, and then exposed to the oligonucleotide array. Based on their pairing oligonucleotide sequences, the capture probes self-assemble at particular array locations. Bound analytes are then detected using a method, such as mass spectrometry, that can be directed toward particular array locations. Because any number and combination of capture probes can be employed, the method is flexible and able to detect analytes at very low concentrations. Additionally, the method provides the ease of detection associated with position-addressable arrays.
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