CELLS EXPRESSING IMMUNOREGULATORY MOLECULES AND USES THEREFOR
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United States of America Patent
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app pub date -
Aug 31, 1998
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Aug 31, 1998
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Abstract
Compositions comprising genetically modified cells which express at least one immunoregulatory molecule and methods for using the genetically modified cells are described. The immunoregulatory molecule expressed by the cell(s) are capable of inhibiting T cell activation and/or natural killer cell-mediated immune response against the cell upon transplantation into a recipient subject. The cells of the invention can express an immunoregulatory molecule on the surface of the cells or secrete the immunoregulatory molecule in soluble form. The cells of the invention can be transplanted into a recipient subject such that immune rejection of the cell is inhibited. In addition, non-human transgenic animals which contain cells which are genetically modified to express at least one immunoregulatory molecule are described.
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