Tris(hydroxymethyl)phosphino compounds as tissue crosslinking agents
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United States of America Patent
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Issued Date -
Aug 15, 2002
app pub date -
Dec 19, 2000
filing date -
Dec 19, 2000
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Abandoned
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Abstract
A method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a fluid comprising a compound comprising P(CH.sub.2OH).sub.3X.sub.n, wherein X is selected from C.sub.1-C.sub.10 carboxyl, sulfonic acid, sulfonic acid salts, C.sub.1-C.sub.10 alcohol, or halogens, and n is an integer from 0 to 2, inclusive, and all --X and --CH.sub.2OH groups are bonded to the phosphorus atom. In one embodiment, the compound is .beta.-(tris(hydroxymethyl)phosphino)proprionic acid (THPP). Also disclosed is a cross-linked biological tissue produced by treating the tissue according to the above method.
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