Efficient methods for the analysis of ion channel proteins
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United States of America Patent
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Issued Date -
Aug 8, 2002
app pub date -
Sep 14, 2001
filing date -
Dec 17, 1997
priority date (Note) -
Abandoned
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Abstract
Methods combining the creation of small bilayer membranes with the fusion of native cell membrane vesicles into those bilayer membranes. By placing a voltage gradient across the lipid bilayer and recording the transmembrane current, the activity of some membrane proteins, such as ion channels, can be analyzed. The methods permit access to a large variety of membrane proteins. The native vesicles may be derived from a variety of cells and intracellular organelles, and as the native cell membrane vesicles may be stored at low temperatures over long periods, the methods reduce the need to maintain cell cultures or obtain primary cells. Fluorescence measurements also may be performed on the bilayer membranes.
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