Human tumor necrosis factor receptor-like 2 (TR2) antibodies
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United States of America Patent
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Issued Date -
Aug 1, 2002
app pub date -
Dec 14, 2001
filing date -
May 12, 1997
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Abstract
The present invention relates to antibodies to novel members of the Tumor Necrosis Factor (TNF) receptor family called TR2 receptor and their uses in pathological conditions. Hybridoma cell lines producing such mAbs, methods of in vivo imaging of pathological conditions, and methods of treating and diagnosing pathological conditions, caused by abnormal functioning, production or metabolism of TR2 receptors are also provided. In vitro assays for detecting the presence of TR2 and for evaluating the binding affinity of a test compound are also described.
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