Transgenic plants with increased expression of VTC4 gene
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United States of America Patent
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Issued Date -
Jul 25, 2002
app pub date -
Jul 20, 2001
filing date -
Mar 29, 1999
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Abandoned
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Abstract
The present invention includes a transgenic plant containing a GDP-mannose pyrophosphorylase gene. A pathway for AsA biosynthesis that features GDP-mannose and L-galactose has recently been proposed for plants. A collection of AsA-deficient mutants of Arabidopsis thaliana that are valuable tools for testing of a novel AsA biosynthetic pathway have been isolated. The best characterized of these mutants (vtc1-vitamin c) contains .about.25% of wildtype AsA and is defective in AsA biosynthesis. Using a combination of biochemical, molecular, and genetic techniques, it has been conclusively demonstrated that the VTC1 locus encodes GDP-mannose pyrophosphorylase (mannose-1-P guanyltransferase). This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation, as well as for AsA biosynthesis.
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