Expression and export of interferon-alpha proteins as Fc fusion proteins

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United States of America Patent

APP PUB NO 20020081664A1
SERIAL NO

09977034

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Abstract

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Disclosed are nucleic acid sequences, for example, DNA or RNA sequences, which encode an immunoglobulin Fc-Interferon-alpha fusion protein. The nucleic acid sequences can be inserted into a suitable expression vector and expressed in mammalian cells. Also disclosed is a family of immunoglobulin Fc-Interferon-alpha fusion proteins that can be produced by expression of such nucleic acid sequences. Also disclosed are methods of using such nucleic acid sequences and/or fusion proteins for treating conditions, for example, hepatitis, which are alleviated by the administration of interferon-alpha.

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Patent Owner(s)

Patent OwnerAddress
EMD LEXIGEN RESEARCH CENTER CORP45A MIDDLESEX TURNPIKE BEDFORD CAMPUS BILLERICA MA 01821

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gillies, Stephen D Carlisle, MA 89 3611
Lo, Kin-Ming Lexington, MA 60 2261
Sun, Yaping Arlington, MA 31 804

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