Prophylactic use of N-methyl-D-aspartate (NMDA) antagonists

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United States of America Patent

APP PUB NO 20020072485A1
SERIAL NO

09969354

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Abstract

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This invention provides a method of inhibiting in a mammal neurological damage resulting from impairment of glucose and/or oxygen supply to the brain, which method comprises administering to the mammal prior to the impairment of glucose and/or oxygen supply to the brain an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in inhibiting neurological damage. This invention also provides a method of preventing primary hyperalgesia, secondary hyperalgesia, primary allodynia, secondary allodynia, or other pain caused by central sensitization, in a mammal, which method comprises administering to the mammal, prior to affliction with said pain, an amount of an NR2B subunit selective NMDA antagonist, which amount is effective in preventing said pain.

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PFIZER INC235 EAST 42ND STREET NEW YORK NY 10017
PFIZER PRODUCTS INCEASTERN POINT ROAD BLDG 188S 3RD FLOOR GROTON CT 06340

International Classification(s)

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  • 2001 Application Filing Year
  • A61K Class
  • 10449 Applications Filed
  • 3517 Patents Issued To-Date
  • 33.66 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2001200220032004200520062007200820092010201120122013201420152016201720180255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chenard, Bertrand L Waterford, CT 95 810
Field, Mark J Great Dunmow, GB 3 14
Menniti, Frank S Mystic, CT 37 382
Saltarelli, Mario D Mystic, CT 11 143
Schneider, Erika Westwood, MA 18 546

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  • 4 Citation Count
  • A61K Class
  • 9.90 % this patent is cited more than
  • 23 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges344181063626215310053322118113601 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +010020030040050060070080090010001100120013001400150016001700180019002000

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