Linker and method for solid phase combinatorial synthesis
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United States of America Patent
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N/A
Issued Date -
Jun 6, 2002
app pub date -
Oct 10, 2001
filing date -
Oct 11, 2000
priority date (Note) -
Abandoned
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Abstract
A high throughput screening method for detecting interactions between proteins, nucleic acids and small molecules comprising coating a solid support surface with a substance, such as streptavidin, that has a high affinity for a ligand, such as biotin, that may be readily attached to a library of compounds via a linker molecule. The biotin linked library members are spotted onto the stretpavidin in a pattern and screened for binding to other compounds of interest. Thus, it is possible to screen much smaller quantities of compounds than would be possible in a multiwell format. Due to the high affinity of biotin for streptavidin, there is no diffusion of the compounds on the solid support. Moreover, the method provides a high throughput, low cost screen that may be accomplished completely manually without the use of expensive fluid handling robots.
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