Bcl-2 gene proteins conjugated to a ligand for a cell surface antigen of a specific cell type
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United States of America Patent
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Issued Date -
May 23, 2002
app pub date -
Oct 10, 2001
filing date -
Oct 10, 2000
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Abandoned
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Abstract
The invention is related to conjugates comprised of a pro-apoptotic protein encoded by Bak, Bak-2 or Bax genes and a ligand specifically targeting a cell surface antigen. The cell surface antigen is expressed on tumor cells, cells infected with bacteria or virus, or cells of specific functions, but it is not expressed or expressed only to a limited extent on other cell types. The ligand my be an organic molecule, an oligonucleotide, peptide, peptidomimetic, monoclonal antibody or derivative thereof, including fragments and single chain antibodies.
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