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Abstract

Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: 1 wherein: R.sup.1 and R.sup.2, which are identical or different, are each hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkyloxy, OH, F, Cl, or Br; R.sup.3 is hydrogen, F, Cl, Br, methyl, ethyl, OH, or methoxy; R.sup.4 and R.sup.5, which are identical or different, are each hydrogen, methyl, or ethyl; R.sup.6 is hydrogen; X is NH.sub.2, NH--(C.sub.1-C.sub.6-alkyl), N(C.sub.1-C.sub.6-alkyl).sub.2-, the two C.sub.1-C.sub.6-alkyl groups of which are identical or different, NH--COH, NH--CO(C.sub.1-C.sub.6-alkyl), or F; A is --(CH.sub.2).sub.3--, --CH.sub.2--CH.sub.2--O--, --CH.sub.2--O--CH.sub.2--, --(CH.sub.2).sub.4--, --CH(C.sub.1-C.sub.6-all-yl)--O--CH.sub.2--, --(CH.sub.2).sub.2--O--CH.sub.2--, --(CH.sub.2).sub.3--O--, --(CH.sub.2).sub.5--, --CH.sub.2--O--(CH.sub.2).-sub.3--, --(CH.sub.2).sub.2--O--(CH.sub.2).sub.2--, --(CH.sub.2).sub.3--O--CH.sub.2--, --(CH.sub.2).sub.4--O--, --CH.sub.2--O--CH.sub.2--CH.sub.2--O--, 2 the racemates thereof, the enantiomers thereof, the diastereomers thereof, and mixtures thereof, and the pharmacologically acceptable acid addition salts thereof, processes for preparing them, and their use as pharmaceutical compositions.

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