Imidazole derivatives and their use as farnesyl protein transferase inhibitors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20020052376A1
SERIAL NO

09955994

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

1 The present invention relates to compound of formula (1), wherein Ar.sup.1 represents (A), or (B), or (C); R.sup.12 and R.sup.13 are independently hydrogen or C.sub.1-4 alkyl; Ar.sup.2 is phenyl or heteroaryl; p is 0 or 1; Ar.sup.3 is phenyl, pyridinyl, pyridazinyl, pyrirmidyl or pyrazynyl the ring being substituted on ring carbon atoms by R.sup.2 and --(CH.sub.2).sub.nR.sup.3 and wherein Ar.sup.3 is attached to Ar.sup.1C(R.sup.12)R.sup.13CH(Ar.sup.2)O-- by a ring carbon atoms; R.sup.2 is a group of formula (2), or R.sup.2 represents a lactone of formula (3), the group of formula (2) or (3) having L or D configuration at the chiral alpha carbon in the corresponding free amino acid; n is 0, 1 or 2; R.sup.3 is phenyl or heteroaryl; and R.sup.5-R.sup.9, m and n are as defined in the specification; or a pharmaceutically acceptable salt, prodrug or solvate thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
ASTRAZENECA UK LIMITED15 STANHOPE GATE LONDON W1K 1LN
ZENECA-PHARMA SA1 RUE DES CAHUFFOURS BOITE POSTALE 127 F-95022 CERGY CEDEX

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnould, Jean-Claude Reims, FR 20 129

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation