Method for the crystallization of iopamidol
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United States of America Patent
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app pub date -
May 9, 2001
filing date -
Nov 9, 1998
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Abstract
Disclosed is the crystallization of Iopamidol using a mixture of an alcohol and water as a crystallization solvent. The ratios of water:Iopamidol from 1:10 to 1:1 (v/w) and alcohol:Iopamidol from 1:1 to 1:10 (v/w) allow Iopamidol to be crystallized to an anhydrous pure form with industrially valuable yields without producing monohydrates and pentahydrates.
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