Aryloxypropanolamine derivatives, method of preparation and applications thereof
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United States of America Patent
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app pub date -
Aug 23, 2001
filing date -
Nov 5, 1996
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Abandoned
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Abstract
The invention concerns aryloxypropanolamnine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with the general formula (I) in which R.sub.2 represents one of the following groups: --CH.sub.2--, --CH.sub.2--CH.sub.2, --CH(CH.sub.3)--CH.sub.2--C(CH.sub.3)---CH--, --C(CH.sub.3).sub.2--CH.sub.2-- or a bond; Q represents: (i) a phenyl radical 3,4-substituted alkylene dioxy determining with the phenyl radical, a non-substituted benaodioxane unit, a non-substituted benzodioxol unit, or a 2-substituted benzodioxol unit, (ii) a phenyl radical 3 and/or 4-substituted, by a O--(CH.sub.2).sub.x--COOR.sub.5 group, (iii) a condensed polycyclic hydrocarbon comprising at least two condensed cycles, (iv) a cyclic hydrocarbon system, optionally cross-linked, and constituting a cycloalkane comprising 1, 2 or 3 cycles. 1
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