CYCLOSPORIN A FORMULATIONS AS NANOPARTICLES
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United States of America Patent
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Issued Date -
Feb 7, 2002
app pub date -
Jul 10, 1998
filing date -
Mar 25, 1996
priority date (Note) -
Abandoned
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Abstract
Cyclosporin A formulations are provided as amorphous nanoparticle dispersions for physiologic absorption.. The compositions have high bioavailability and patient acceptability. By providing for concentrates comprising lower alkanols and a polyoxyalkylene surfactant as a stable dispersion of cyclosporin A, upon introducing the stable dispersion into an aqueous medium, the subject formulation is produced comprising amorphous bioavailable cyclosporin nanoparticles.
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