ELECTROCHEMICAL PROBES FOR DETECTION OF MOLECULAR INTERACTIONS AND DRUG DISCOVERY
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United States of America Patent
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Issued Date -
Jan 31, 2002
app pub date -
Feb 6, 1998
filing date -
Feb 6, 1997
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Abandoned
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Abstract
This invention relates to methods and apparati for performing electrochemical analyses. The invention provides an electrochemical apparatus for performing potentio metric analyses for detecting specific binding between a first member of a biological binding pair immobilized on an electrode and a second member of a biological binding pair that is electrochemically labeled, in the presence of an electrochemical mediator. Methods for using the apparatus of the invention for performing binding and competition binding assays are provided. The invention also provides methods for performing high throughput screening assays for detecting inhibition of specific binding between the members of the biological binding pair for use in drug development, biochemical analysis and protein purification assays.
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