METHOD OF PREPARING A SOMATIC CELLS FOR NUCLEAR TRANSFER
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United States of America Patent
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Issued Date -
Jan 31, 2002
app pub date -
Dec 30, 1999
filing date -
Mar 4, 1999
priority date (Note) -
Abandoned
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Abstract
The production of genetically modified animals, in which the genetic modifications are engineered in somatic cells cultured in vitro by gene targeting, is described. Genetically modified cells may then used as nuclear donors to produce, inter alia, live animals. The methods described can also be used to validate loci in animal chromosomes which are suitable sites for transgene addition to cells.
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