SYNTHETIC PEPTIDE VACCINES FOR DENTAL CARIES
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United States of America Patent
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app pub date -
Nov 10, 1997
filing date -
May 1, 1992
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Abstract
Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, aspartate 415 or both aspartate 413 and aspartate 415. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.
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