IMMUNE CELL REGULATION WITH SRC PTK SEQUESTERING AGENTS
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United States of America Patent
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Issued Date -
Dec 6, 2001
app pub date -
Apr 1, 1998
filing date -
Apr 1, 1998
priority date (Note) -
Abandoned
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Abstract
Signal propagation in MIRR-coupled immune cell signalling pathways is extinguished or curtailed by sequestering Src family enzymes indigenous to the cell. Signal-curtailing ligands which cross-link MIRR extracellular domains and stabilize intra-cellular Src/MIRR complexes are exemplary sequestering agents which function as immune cell antagonists.
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