Method for producing model animals for itching induced by disruption of cutaneous barrier function
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United States of America Patent
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Issued Date -
Nov 22, 2001
app pub date -
Apr 11, 2001
filing date -
May 17, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides itching model animals usable for evaluating the therapeutic effect of medicines, medicinal compositions, external preparations for the skin, etc. on itching induced by hypofunction of cutaneous barrier and also for evaluating the effect in improving the barrier function of the skin weakened and converted to be itchy by an external preparation for the skin or a cosmetic. The present invention also provides a method for producing such animals. Itching symptoms are realized by degreasing the glabrous skin of each of small test animals with an organic solvent and then treating the skin with water to induce a lesion of the skin by the disruptions of the barrier function without inflammation.
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