Production process for polymeric micelle charged therein with drug and polymeric micelle composition
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United States of America Patent
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Issued Date -
Aug 16, 2001
app pub date -
Feb 8, 2001
filing date -
Feb 9, 2000
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Abandoned
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Abstract
Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.
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