Process for preparing imetelstat

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12264174
APP PUB NO 20240262854A1
SERIAL NO

18435848

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Abstract

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The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3′-amino group of the support-bound oligonucleotide, coupling with a 5′-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3′-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.

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Patent Owner(s)

Patent OwnerAddress
GERON CORPORATION149 COMMONWEALTH DRIVE MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Albaneze-Walker, Jennifer Elizabeth Beerse, BE 5 0
Gala, Dinesh Beerse, BE 26 35
Muslehiddinoglu, Jale Beerse, BE 7 9

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