7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use

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United States of America

PATENT NO 12263171
APP PUB NO 20230054411A1
SERIAL NO

17294836

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Abstract

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In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ali, Amjad Freehold, US 82 315
Cumming, Jared Winchester, US 5 4
DeMong, Duane Hanover, US 24 78
Deng, Qiaolin Edison, US 31 115
Graham, Thomas H Somerville, US 43 217
Hennessy, Elisabeth Cambridge, US 9 7
Larsen, Matthew A Dedham, US 16 27
Liu, Kun Needham, US 450 3287
Liu, Ping Westfield, US 587 9247
Mansoor, Umar Faruk Hopkinton, US 28 257
Pan, Jianping Monmouth Junction, US 55 284
Plummer, Christopher W Westfield, US 22 59
Sather, Aaron Melrose, US 4 4
Swaminathan, Uma Auburndale, US 9 4
Wang, Huijun Westfield, US 49 237
Zhang, Yonglian East Brunswick, US 22 58

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