Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as a Syk inhibitor

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United States of America

PATENT NO 12263163
APP PUB NO 20230158023A1
SERIAL NO

18057195

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Abstract

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The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, a Syk inhibitor is a crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo-[1,2-a]pyrazin-8-amine of formula 2:

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Patent Owner(s)

  • KRONOS BIO, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blomgren, Peter A Issaquah, US 74 1440
Currie, Kevin S North Bend, US 96 2764
Kropf, Jeffrey E Issaquah, US 64 1218
Lee, Seung H Sammamish, US 59 1097
Lo, Jennifer R Seattle, US 20 192
Mitchell, Scott A Kenmore, US 75 2552
Schmitt, Aaron C Hamden, US 27 643
Swaminathan, Sundaramoorthi Burlingame, US 47 1445
Xiong, Jin-Ming Bel Air, US 10 123
Xu, Jianjun Bellevue, US 96 1261
Zhao, Zhongdong Bellevue, US 45 698

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