System for scale-down the processes of freezing and thawing aqueous solutions of thermo-sensitive pharmaceuticals

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United States of America

PATENT NO 12262709
APP PUB NO 20210392875A1
SERIAL NO

17463093

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Abstract

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This disclosure relates to scale-down systems for freezing and thawing aqueous liquid mixtures of thermo sensitive substances. In at least one aspect, the system can comprise a first container that has a head-space and a liquid-space, with a substantially constant average transversal cross-section area in the liquid-space that does not change substantially with height. The first container holds a volume of liquid for a height of liquid, has a lateral active heat transfer area having an insulated lateral area ALIM, and has an equivalent radius sized to reproduce the equivalent radius of a second container. The first container further has a lateral heat transfer area in contact with the liquid-space. The first container is smaller than the second container, and the insulated lateral area is equal to or greater than the lateral active heat transfer area.

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Patent Owner(s)

Patent OwnerAddress
SMARTFREEZ LDA2740-122 PORTO SALVO

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Brito Estrela Rui Lisbon, PT 7 5
Sena, Rego Pedro Gil Lisbon, PT 6 2
Silvestre, Duarte Andreia Filipa Sacavém, PT 9 5

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