Polyclonal mixtures of antibodies, and methods of making and using them
Number of patents in Portfolio can not be more than 2000
United States of America
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Mar 25, 2025
Grant Date -
Mar 9, 2023
app pub date -
Jun 13, 2022
filing date -
Jun 13, 2022
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Abstract
A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies. Host cells expressing antibodies that bind to the antigen are then collected from among the first plurality of host cells, and a composition is prepared comprising a polyclonal mixture of antibodies expressed by these host cells. A second sample of the antigen of interest is then contacted with an aliquot of the prepared composition and a second plurality of host cells collectively expressing a second library of antibodies. Host cells expressing antibodies that bind to the second sample of the antigen are then collected from among the second plurality of host cells.
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