strains expressing modified gluconate repressor proteins GntR1 and GntR2

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United States of America

PATENT NO 12258600
APP PUB NO 20240271169A1
SERIAL NO

18693613

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C. glutamicum strains express modified gluconate repressor proteins GntR1 and GntR2. The C. glutamicum strains have an increased ability to produce L-lysine compared with an ability of a wildtype strain. The gluconate repressor protein GntR1 includes an amino acid sequence of SEQ ID NO: 9, where the amino acid Arg in position 102 is replaced by the amino acid Glu. The gluconate repressor protein GntR2 includes SEQ ID NO: 10, and its activity is attenuated compared to the activity of the GntR2 repressor protein of the wild-type strain. A method is developed for the fermentative production of L-lysine using such C. glutamicum strains.

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  • EVONIK OPERATIONS GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bathe, Brigitte Salzkotten, DE 133 761
Jankowitsch, Frank Sassenberg, DE 3 0
Jerrentrup, Silke Bielefeld, DE 5 15
Voß, Kornelia Antwerp, BE 5 8

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