Systems, methods and compositions for sequence manipulation with optimized functional CRISPR-Cas systems

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United States of America

PATENT NO 12258595
APP PUB NO 20240035007A1
SERIAL NO

18089023

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Abstract

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The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.

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Patent Owner(s)

Patent OwnerAddress
PRESIDENT AND FELLOWS OF HARVARD COLLEGE17 QUINCY STREET CAMBRIDGE MA 02138

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brigham, Mark Cambridge, US 7 239
Hsu, Patrick Cambridge, US 33 2327
Ishitani, Ryuichiro Tokyo, JP 14 70
Konermann, Silvana Cambridge, US 41 828
Lin, Chie-Yu Cambridge, US 12 497
Nishimasu, Hiroshi Tokyo, JP 21 99
Nureki, Osamu Tokyo, JP 20 115
Ran, Fei Cambridge, US 52 6750
Trevino, Alexandro Cambridge, US 4 58
Zhang, Feng Cambridge, US 1002 28040

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