Complement component C3 iRNA compositions and methods of use thereof

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United States of America

PATENT NO 12258565
APP PUB NO 20240209369A1
SERIAL NO

18594132

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Abstract

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The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the complement component C3 gene (C3). The invention also relates to methods of using such RNAi agents to inhibit expression of a C3 gene and to methods of preventing and treating a C3-associated disorder, e.g., cold agglutinin disease (CAD), warm autoimmune hemolytic anemia, and paroxysmal nocturnal hemoglobinuria (PNH), lupis nephritis (LN), bullous pemphigoid, pemphigus, e.g., pemphigus vulgaris (PV) and pemphigus foliaceus (PF), and C3 glomerulopathy.

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Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INC300 THIRD STREET 3RD FLOOR CAMBRIDGE MA 02142-1110

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Castoreno, Adam Framingham, US 62 8
Fishilevich, Elane Rochester, US 48 15
Kaittanis, Charalambos Cambridge, US 42 26
Keating, Mark Weston, US 24 75
McIninch, James D Burlington, US 80 141
Schlegel, Mark K Boston, US 71 33
Solomon, Sarah Cambridge, US 2 1
Yucius, Kristina Burlington, US 5 3

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