Preparation of therapeutic exosomes using membrane proteins

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12257313
APP PUB NO 20240009322A1
SERIAL NO

18050005

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Abstract

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The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

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Patent Owner(s)

Patent OwnerAddress
LONZA SALES AGMÜNCHENSTEINERSTRASSE 38 BASEL 4052

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dooley, Kevin P Boston, US 16 29
Harrison, Rane A Belmont, US 9 28
Haupt, Sonya Cambridge, US 8 28
Houde, Damian J Plymouth, US 11 29
Kulman, John D Belmont, US 11 35
McConnell, Russell E Brighton, US 14 28
Ross, Nikki Cambridge, US 8 23
Williams, Douglas E Boston, US 31 246
Xu, Ke Sudbury, US 254 720

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