Composition comprising naphthoquinone-based compound as active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment
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United States of America
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Mar 25, 2025
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Mar 21, 2019
app pub date -
Apr 28, 2017
filing date -
Apr 28, 2017
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Abstract
The present invention relates to a composition comprising a naphthoquinone-based compound as an active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline, and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment. Specifically, it has been confirmed that the naphthoquinone-based compounds, dunnione and β-lapachone, reduce the secretion and production of inflammatory cytokines which are increased by the anticancer drug treatment, and prevent fatigue, cachexia, cognitive decline, and hematopoietic stem cell reduction which are side effects associated with anticancer drug treatment, and thus the dunnione and β-lapachone compounds, pharmaceutically acceptable salts, prodrugs, solvates or isomers thereof can be effectively used as a pharmaceutical composition for preventing or ameliorating any one or more side effects related to anticancer drug treatment selected from the group consisting of fatigue, cachexia, pain, cognitive decline, and hematopoietic stem cell reduction.
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