Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach

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United States of America

PATENT NO 12256979
APP PUB NO 20210369334A1
SERIAL NO

17404895

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Abstract

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Methods and apparatus are provided for pulsed electric field (PEF) neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, an apparatus includes an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

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Patent Owner(s)

Patent OwnerAddress
MEDTRONIC IRELAND MANUFACTURING UNLIMITED COMPANYDUBLIN 2 D02 T380

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clark, Benjamin J Redwood City, US 108 17067
Gifford,, III Hanson S Woodside, US 185 8731
Thai, Erik Mountain View, US 74 14935
Zadno, Nicolas Fremont, US 60 12523
Zarins, Denise Los Gatos, US 150 10176

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