Preparation method and application of water-soluble chlorhexidine hyaluronate antibacterial agents

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United States of America

PATENT NO 12256737
APP PUB NO 20240292841A1
SERIAL NO

18662301

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Disclosed are a water-soluble chlorhexidine antimicrobial agent and a preparation method therefor and use thereof. The present disclosure takes hyaluronic acid as a raw material to prepare a hyaluronic acid aqueous solution or organic solution, then the hyaluronic acid aqueous solution or organic solution and a chlorhexidine solution are subjected to a complexation reaction, an insoluble substance therein is removed, and then the resulting solution is dried to obtain the water-soluble chlorhexidine antimicrobial agent, namely hyaluronic acid chlorhexidine. The hyaluronic acid chlorhexidine has a good broad-spectrum antimicrobial performance, and excellent water solubility. The hyaluronic acid chlorhexidine combines advantages of hyaluronic acid and chlorhexidine, has good biocompatibility, no cytotoxicity, no skin irritation, and good moisture retention, can be prepared into an antimicrobial aqueous solution or gel, ointment and other products, and is used in the fields of medical devices, skin wound nursing, oral nursing, personal hygiene, environmental disinfection and the like.

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Patent Owner(s)

Patent OwnerAddress
JIANGNAN UNIVERSITYNO 1800 ROAD 214122 JIANGSU LIHU BINHU DISTRICT CITY OF WUXI PROVINCE WUXI CITY JIANGSU PROVINCE 214122
SHANDONG AMHWA BIOPHARM CO LTDNO 488 HUANGHE 12TH ROAD SHANDONG PROVINCE BINZHOU CITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dong, Ying Wuxi, CN 43 224
Feng, Huiru Wuxi, CN 1 0
Gong, Kai Wuxi, CN 17 37
Han, Xiuyun Binzhou, CN 1 0
Li, Haoran Wuxi, CN 74 94
Liu, Yanqin Wuxi, CN 21 6
Yu, Xiangxiang Wuxi, CN 1 0
Zhang, Huimin Wuxi, CN 66 385

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