Direct structured illumination microscopy reconstruction method

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United States of America

PATENT NO 12254592
APP PUB NO 20230214961A1
SERIAL NO

17998484

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A direct structured illumination microscopy (dSIM) reconstruction method is provided. First, a time domain modulation signal is extracted through a wavelet. Then, an incoherent signal is converted into a coherent signal. Next, an accumulation amount at each pixel is calculated. Finally, a super-resolution image is generated by using a correlation between signals at different spatial positions. An autocorrelation algorithm of dSIM is insensitive to an error of a reconstruction parameter. dSIM bypasses a complex frequency domain operation in structured illumination microscopy (SIM) image reconstruction, and prevents an artifact caused by the parameter error in the frequency domain operation. The dSIM algorithm has high adaptability and can be used in laboratory SIM, nonlinear SIM imaging systems, or commercial systems.

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Patent Owner(s)

  • PEKING UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dai, Qionghai Beijing, CN 37 85
Jiang, Shan Beijing, CN 110 1913
Qiao, Hui Beijing, CN 18 106
Xi, Peng Beijing, CN 5 22

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