Selectively controllable cleavable linkers

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12252739
APP PUB NO 20230151411A1
SERIAL NO

18156511

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Abstract

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Selectively controllable cleavable linkers include electrochemically-cleavable linkers, photolabile linkers, thermolabile linkers, chemically-labile linkers, and enzymatically-cleavable linkers. Selective cleavage of individual linkers may be controlled by changing local conditions. Local conditions may be changed by activating electrodes in proximity to the linkers, exposing the linkers to light, heating the linkers, or applying chemicals. Selective cleaving of enzymatically-cleavable linkers may be controlled by designing the sequences of different sets of the individual linkers to respond to different enzymes. Cleavable linkers may be used to attach polymers to a solid substrate. Selective cleavage of the linkers enables release of specific polymers from the solid substrate. Cleavable linkers may also be used to attach protecting groups to the ends of growing polymers. The protecting groups may be selectively removed by cleavage of the linkers to enable growth of specific polymers.

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Patent Owner(s)

  • MICROSOFT TECHNOLOGY LICENSING, LLC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Nguyen, Bichlien Hoang Seattle, US 37 61
Strauss, Karin Seattle, US 104 1266

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