Ketoreductase polypeptides and polynucleotides

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12252723
APP PUB NO 20240068005A1
SERIAL NO

18352899

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Abstract

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The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

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Patent Owner(s)

  • CODEXIS INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dellas, Nikki San Carlos, US 61 39
Duan, Da Newark, US 30 14
Farasat, Iman Rahway, US 8 4
Liang, Jack South San Francisco, US 45 446
Marshall, Nicholas Rahway, US 35 109
Mitchell, Vesna Santa Clara, US 65 314
Moore, Jeffrey C Westfield, US 102 1274
Murphy, Grant Rahway, US 8 7
Nazor, Jovana Milpitas, US 78 206
Penfield, Jonathan Truckee, US 3 0
Rodriguez-Granillo, Agustina Rahway, US 18 14

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