Closed-ended linear duplex DNA for non-viral gene transfer

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United States of America

PATENT NO 12252703
APP PUB NO 20210355507A1
SERIAL NO

17335499

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Abstract

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Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise-symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.

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Patent Owner(s)

Patent OwnerAddress
VOYAGER THERAPEUTICS INC64 SIDNEY STREET CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cecchini, Sylvain Worcester, US 5 8
Kotin, Robert M Worcester, US 23 774

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