Recombinant poxviruses for cancer immunotherapy

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United States of America

PATENT NO 12252702
APP PUB NO 20220056475A1
SERIAL NO

17275974

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Abstract

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Disclosed herein are methods and compositions related to the treatment, prevention, and/or amelioration of cancer in a subject in need thereof. In particular aspects, the present technology relates to the use of genetically engineered or recombinant poxviruses, including a modified vaccinia Ankara (MVA) virus comprising a deletion of E3L (MVAΔE3L) engineered to express OX40L (MVAΔE3L-OX40L), an MVA virus comprising a deletion of C7L (MVAΔC7L) engineered to express OX40L (MVAΔC7L-OX40L), a MVAΔC7L engineered to express OX40L and human Fms-like tyrosine kinase 3 ligand (hFlt3L) (MVAΔC7L-hFlt3L-OX40L), an MVA comprising a deletion of E5R (MVAΔE5R), a vaccinia virus comprising a deletion of C7L (VACVΔC7L) engineered to express OX40L (VACVΔC7L-OX40L), a VACVΔC7L engineered to express both OX40L and hFlt3L (VACVΔC7L-hFlt3L-OX40L), a VACV comprising a deletion of E5R (VACVΔE5R), a myxoma virus (MYXV) comprising a deletion of M31R (MYXVΔM31R), or combinations thereof, alone or in combination with other agents, as an oncolytic and immunotherapeutic composition.

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Patent Owner(s)

Patent OwnerAddress
MEMORIAL SLOAN KETTERING CANCER CENTER1275 YORK AVENUE NEW YORK NY 10065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dai, Peihong New York, US 14 40
Deng, Liang New York, US 40 141
Mazo, Gregory New York, US 1 1
Merghoub, Taha New York, US 72 265
Shuman, Stewart New York, US 38 270
Wang, Weiyi New York, US 95 481
Wang, Yi New York, US 1349 14754
Wolchok, Jedd New York, US 18 55
Yang, Ning New York, US 464 1757

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