Engineering gut commensal bacteria to express heterologous proteins in their outer membrane vesicles (OMVS) for delivery to the GI-tract

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United States of America

PATENT NO 12251433
SERIAL NO

17316219

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Abstract

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This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.

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Patent Owner(s)

  • QUADRAM INSTITUTE BIOSCIENCE; UEA ENTERPRISES LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carding, Simon Richard Norwich, GB 2 1
Stentz, Regis Gabriel Norwich, GB 2 1

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