3D printed micro-millifluidic bioreactors for long-term retinal organoid maintenance

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 12247220
APP PUB NO 20230077412A1
SERIAL NO

17903458

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A bioreactor device includes a solid substrate having a first face and a second face. The solid substrate at least partially defines a perfusion channel, a plurality of chambers, a fluidic inlet, and a fluidic outlet. A first sheet disposed over the first face and a second sheet disposed over the second face. Characteristically, the combination of the solid substrate, the first sheet and the second sheet define the perfusion channel and each chamber of the plurality of chambers. The plurality of chambers are arranged in rows of chambers in which adjacent chambers are positioned at opposite side of the perfusion channel. The perfusion channel extends from the fluidic inlet and the fluidic outlet having a serpentine path along each row of chambers with each chamber being in fluid communication with the perfusion channel.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Browne, Andrew W Newport Coast, US 5 6
Seiler, Magdalene J Orange, US 4 194
Tang, William C Irvine, US 11 570
Xue, Yuntian Irvine, US 1 0

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