Photo-coupled synergistically crosslinked hydrogel material and its composition, preparation method, use, product, and preparation kit

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United States of America

PATENT NO 12247089
APP PUB NO 20200262939A1
SERIAL NO

16848352

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Abstract

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This invention provides a preparation, composition, product, and application of a photo-coupled synergistically crosslinked hydrogel material. The preparation includes dissolving Component A including a photosensitive polymer derivative having o-nitrobenzyl phototriggers and Component B including a polymer derivative having amine or alkene (double group) or sulfhydryl group in a biocompatible medium to obtain solution A and solution B, respectively; mixing the solution A and solution B homogeneously to obtain a hydrogel precursor solution; initiating photo-coupled synergistic crosslinking under an irradiation of a UV light to form the hydrogel. The irradiation causes the o-nitrobenzyl phototriggers to generate an aldehyde group/keto group or a nitroso group to initiate photo-coupled synergetic crosslinking. The photo-coupled synergistically crosslinked hydrogel has applications in tissue engineering, regenerative medicine, 3D printing and as a carrier of cell, protein or drug.

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Patent Owner(s)

  • ZHONGSHAN GUANGHE MEDICAL TECHNOLOGY CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bao, Chunyan Shanghai, CN 7 5
Hua, Yujie Shanghai, CN 3 1
Lin, Qiuning Shanghai, CN 9 5
Zhang, Yiqing Shanghai, CN 4 1
Zhong, Xuepeng Shanghai, CN 2 1
Zhu, Linyong Shanghai, CN 9 5

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