System and method for the activation of active ion transporters without the consumption of adenosine triphosphate (ATP) molecules for the treatment of limb ischemia

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United States of America

PATENT NO 12246176
SERIAL NO

18185523

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Abstract

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A system and method for treatment of ischemia limb by operating the sodium-potassium (Na/K) pumps of the ischemia limb to consume one ATP to actively extrude 3 Na+ and pumping in 2 K+ ions, synchronizing the Na/K pump molecules down to individual steps in a pumping cycle and then switching to a noncanonical mode to synthesize one ATP molecule at end of each pumping cycle. The synthesis of ATP molecule compensates the ATP consumed in actively transporting ions. As a result, the zero-consumption of ATP for the electrically modulated Na/K pumps controlled by the system and method of the present invention save the residual limited ATP molecules in the ischemia limb to maintain the living environment of the cells in the ischemia limb, and therefore recover the functions of the limb.

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Patent Owner(s)

Patent OwnerAddress
WR BIOTECH LLC3802 SPECTRUM BOULEVARD 142A TAMPA FL 33612

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Wei Tampa, US 2011 24064
Liu, Ruisheng Tampa, US 5 13

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